RESEARCH >> Theme: ion transport across lipid bilayers
A new research project developed in the EMNS Lab deals with ion transport across lipid membranes using supramolecular carriers.
Channel-forming membrane proteins are responsible for the transport of charged species through cell membranes. Dysfunction in ion transport is the cause of numerous diseases, of which cystic fibrosis is probably the most well-known. It is possible to compensate for the defect or under-expressed membrane protein channel activity by using synthetic molecules which can carry anions through the lipid bilayer. Our goal is to study the thermodynamics, kinetics, and structural parameters of anion carriers inside lipid bilayer membranes in order to highlight the key parameters governing the efficiency of organic receptors as transporters. We use both state-of-the-art physical organic chemistry and biophysical methods, such as advanced NMR techniques, microcalorimetry and fluorescence spectroscopy, to obtain an extensive understanding of the transport phenomenon and propose new rules for the design of the next generation of anion transporters.
Co-workers/researchers: Ir Glenn Grauwels
Collaborations: Prof. Tony Davis (University of Bristol), Prof. Ivan Jabin (ULB)
Funding: FNRS (Post-doctoral and PhD fellowships)
H. Valkenier, C. M. Dias, C. P. Butts, A. P. Davis, Tetrahedron, in press (2017).
S. J. Edwards, I. Marques, C. M. Dias, R. A. Tromans, N. R. Lees, V. Félix, H. Valkenier, A. P. Davis, Chem. Eur. J., 22, 2004-2011 (2016).
H. Li, H. Valkenier, L. W. Judd, P. R. Brotherhood, S. Hussain, J. A. Cooper, O. Jurček, H. A. Sparkes, D. N. Sheppard, A. P. Davis, Nature Chemistry 8, 24-31 (2016).
H. Valkenier, L.W. Judd, H. Li, S. Hussain, D.N. Sheppard, A.P. Davis, J. Am. Chem. Soc. 136, 12507-12512 (2014).
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